// genesis 2.2 // Kerstin Menne // Medical University of Luebeck, 02.10.2001 // // prototype Ca channels and Ca concentration for pyramidal cells and // interneurons // taken from BABEL/babeldirs/cells/traub94/traub94proto.g // somatic Ca decay time for interneurons according to // Traub, R.D. and Miles, R., Pyramidal Cell-to-Inhibitory Cell // Spike Transduction Explicable by Active Dendritic Conductances in // Inhibitory Cell, Journal of Computational Neuroscience, 2, 291-298 (1995) //======================================================================== // Tabulated Ca Channel //======================================================================== function make_Ca if (({exists Ca})) return end create tabchannel Ca // V // S // A // S setfield ^ Ek {ECA} Gbar 1 Ik 0 Gk 0 Xpower 2 \ Ypower 0 Zpower 0 // Converting Traub's expressions for the gCa/s alpha and beta functions // to SI units and entering the A, B, C, D and F parameters, we get: setupalpha Ca X 1.6e3 0 1.0 {-1.0*(0.065 + EREST_ACT)} \ -0.01389 {-20e3*(0.0511 + EREST_ACT)} 20e3 -1.0 \ {-1.0*(0.0511 + EREST_ACT)} 5.0e-3 end //======================================================================== // Ca concentration //======================================================================== function make_Ca_conc if (({exists Ca_conc})) return end create Ca_concen Ca_conc // 0.01333 sec // Curr to conc for soma setfield Ca_conc tau 0.020 B 17.402e12 Ca_base 0.0 if (!{exists Ca_conc sendmsg1}) addfield Ca_conc sendmsg1 end setfield Ca_conc sendmsg1 "../Ca . I_Ca Ik" end function make_Ca_conc_soma if (({exists Ca_concs})) return end create Ca_concen Ca_concs // 0.01333 sec // Curr to conc for soma setfield Ca_concs tau 1.0 B 17.402e12 Ca_base 0.0 if (!{exists Ca_concs sendmsg1}) addfield Ca_concs sendmsg1 end setfield Ca_concs sendmsg1 "../Ca . I_Ca Ik" end // ================================================== // for interneurons somatic Ca decay time is much faster, compared to pyramidal // cell // ================================================= function make_Ca_conc_somai if (({exists Ca_concsi})) return end create Ca_concen Ca_concsi // 0.01333 sec // Curr to conc for soma setfield Ca_concsi tau 0.333 B 17.402e12 Ca_base 0.0 if (!{exists Ca_concsi sendmsg1}) addfield Ca_concsi sendmsg1 end setfield Ca_concsi sendmsg1 "../Ca . I_Ca Ik" end