// genesis 2.2 // Kerstin Menne // Medical University of Luebeck, 23.10.2001 // // cell descriptor file for feedback inhibitory interneurons with input from // pyramidal cells; incorporation of synaptically activated channels // // data taken from: Pyramidal Cell-to-Inhibitory Cell Spike Transduction // Explicable by Active Dendritic Conductances in Inhibitory Cell; R.D.Traub, // R. Miles; (1995) Journal of Computational Neuroscience, 2, 291-298 // information about synapses from: // Cellular mechanisms of 4-aminopyridine-induced synchronized after- // discharge in the rat hippocampal slice, Traub et al., 1995, Journal of // Physiology, 489.1, pp.127-140 // and // On the Mechanisms of the gamma->beta Frequency Shift in Neuronal // Oscillations Induced in Rat Hippocampal Slices by Tetanic Stimulation // Traub et al, 1999, The Journal of Neuroscience, 19(3), pp. 1088-1105 *cartesian // use cartesian coordinates *relative // coordinates are relative to each other *asymmetric // use asymmetric compartments *set_compt_param RM 5.0 // ohm*m^-2 *set_compt_param RA 2.0 // ohm*m^-1 *set_compt_param CM 0.0075 // F/m^-2 *set_compt_param ELEAK -0.06 // V // The format for each compartment parameter line is : // name parent x y z diameter [channel dens] // For channels, "dens" = maximum conductance per unit area of compartment // The compartment numbering corresponds to that in the paper, with soma = 4 *spherical //soma is a sphere (in paper: cylinder); radius adjusted to have //same area soma none 0 0 20 17.4 Ca_concsi -24.0e12 Na 1000 Ca 10 K_DRi 1350 K_AHPsi 0.1 K_Csi 200 K_Ai 5 *cylindrical //axon segments and dendrites are cylindrical; dendrites without //spines -> no changes in RM and CM ap5_1 soma -50 0 0 3.00 Ca_conc -18.0e12 Na 250 Ca 10 K_DRi 250 K_AHPi 0.1 K_Ci 80 K_Ai 5 ap5_2 soma -45.83 0 20 3.00 Ca_conc -18.0e12 Na 250 Ca 10 K_DRi 250 K_AHPi 0.1 K_Ci 80 K_Ai 5 ap5_3 soma -41.5 0 27.89 3.00 Ca_conc -18.0e12 Na 250 Ca 10 K_DRi 250 K_AHPi 0.1 K_Ci 80 K_Ai 5 ap5_4 soma 0 41.5 27.89 3.00 Ca_conc -18.0e12 Na 250 Ca 10 K_DRi 250 K_AHPi 0.1 K_Ci 80 K_Ai 5 ap5_5 soma 0 45.83 20 3.00 Ca_conc -18.0e12 Na 250 Ca 10 K_DRi 250 K_AHPi 0.1 K_Ci 80 K_Ai 5 ap5_6 soma 0 50 0 3.00 Ca_conc -18.0e12 Na 250 Ca 10 K_DRi 250 K_AHPi 0.1 K_Ci 80 K_Ai 5 ap6_1 ap5_3 -50 0 0 1.88 Ca_conc -29.0e12 Na 250 Ca 10 K_DRi 250 K_AHPi 0.1 K_Ci 80 K_Ai 5 AMPA -4.0e-9 ap6_2 ap5_4 0 50 0 1.88 Ca_conc -29.0e12 Na 250 Ca 10 K_DRi 250 K_AHPi 0.1 K_Ci 80 K_Ai 5 AMPA -4.0e-9 ap6_3 ap5_5 0 50 0 1.88 Ca_conc -29.0e12 Na 250 Ca 10 K_DRi 250 K_AHPi 0.1 K_Ci 80 K_Ai 5 AMPA -4.0e-9 ap6_4 ap5_6 0 50 0 1.88 Ca_conc -29.0e12 Na 250 Ca 10 K_DRi 250 K_AHPi 0.1 K_Ci 80 K_Ai 5 AMPA -4.0e-9 ap7_1 ap6_1 -50 0 0 1.88 Ca_conc -37.0e12 Na 500 Ca 10 K_DRi 500 K_AHPi 0.1 K_Ci 40 K_Ai 0 AMPA -4.0e-9 ap7_2 ap6_2 0 50 0 1.88 Ca_conc -37.0e12 Na 500 Ca 10 K_DRi 500 K_AHPi 0.1 K_Ci 40 K_Ai 0 AMPA -4.0e-9 ap7_3 ap6_3 0 50 0 1.20 Ca_conc -37.0e12 Na 500 Ca 10 K_DRi 500 K_AHPi 0.1 K_Ci 40 K_Ai 0 AMPA -4.0e-9 ap7_4 ap6_3 -48 0 14 1.20 Ca_conc -37.0e12 Na 500 Ca 10 K_DRi 500 K_AHPi 0.1 K_Ci 40 K_Ai 0 AMPA -4.0e-9 ap7_5 ap6_4 0 50 0 1.88 Ca_conc -37.0e12 Na 500 Ca 10 K_DRi 500 K_AHPi 0.1 K_Ci 40 K_Ai 0 AMPA -4.0e-9 ap8_1 ap7_1 -49.5 0 7.05 1.88 Ca_conc -13.0e12 Na 250 Ca 10 K_DRi 250 K_AHPi 0.1 K_Ci 40 K_Ai 0 AMPA -4.0e-9 ap8_2 ap7_2 0 49.5 7.05 1.88 Ca_conc -13.0e12 Na 250 Ca 10 K_DRi 250 K_AHPi 0.1 K_Ci 40 K_Ai 0 AMPA -4.0e-9 ap8_3 ap7_3 0 50 0 1.20 Ca_conc -13.0e12 Na 250 Ca 10 K_DRi 250 K_AHPi 0.1 K_Ci 40 K_Ai 0 AMPA -4.0e-9 ap8_4 ap7_4 -48 0 14 1.20 Ca_conc -13.0e12 Na 250 Ca 10 K_DRi 250 K_AHPi 0.1 K_Ci 40 K_Ai 0 AMPA -4.0e-9 ap8_5 ap7_5 0 50 0 1.88 Ca_conc -13.0e12 Na 250 Ca 10 K_DRi 250 K_AHPi 0.1 K_Ci 40 K_Ai 0 AMPA -4.0e-9 ap9_1 ap8_1 -49.5 0 7.05 1.88 Ca_conc -16.0e12 Na 0 Ca 10 K_DRi 0 K_AHPi 0.1 K_Ci 40 K_Ai 0 ap9_2 ap8_2 0 49.5 7.05 1.88 Ca_conc -16.0e12 Na 0 Ca 10 K_DRi 0 K_AHPi 0.1 K_Ci 40 K_Ai 0 ap9_3 ap8_3 -45.83 0 20 0.76 Ca_conc -16.0e12 Na 0 Ca 10 K_DRi 0 K_AHPi 0.1 K_Ci 40 K_Ai 0 ap9_4 ap8_3 0 50 0 0.76 Ca_conc -16.0e12 Na 0 Ca 10 K_DRi 0 K_AHPi 0.1 K_Ci 40 K_Ai 0 ap9_5 ap8_4 -48 0 14 1.20 Ca_conc -16.0e12 Na 0 Ca 10 K_DRi 0 K_AHPi 0.1 K_Ci 40 K_Ai 0 ap9_6 ap8_5 0 50 0 1.88 Ca_conc -16.0e12 Na 0 Ca 10 K_DRi 0 K_AHPi 0.1 K_Ci 40 K_Ai 0 ap10_1 ap9_1 -45.83 0 20 1.20 Ca_conc -25.0e12 Na 0 Ca 10 K_DRi 0 K_AHPi 0.1 K_Ci 40 K_Ai 0 ap10_2 ap9_1 0 45.83 20 1.20 Ca_conc -25.0e12 Na 0 Ca 10 K_DRi 0 K_AHPi 0.1 K_Ci 40 K_Ai 0 ap10_3 ap9_2 0 49.5 7.05 1.88 Ca_conc -25.0e12 Na 0 Ca 10 K_DRi 0 K_AHPi 0.1 K_Ci 40 K_Ai 0 ap10_4 ap9_3 -50 0 0 0.76 Ca_conc -25.0e12 Na 0 Ca 10 K_DRi 0 K_AHPi 0.1 K_Ci 40 K_Ai 0 ap10_5 ap9_4 0 48 14 0.76 Ca_conc -25.0e12 Na 0 Ca 10 K_DRi 0 K_AHPi 0.1 K_Ci 40 K_Ai 0 ap10_6 ap9_5 -48 0 14 1.20 Ca_conc -25.0e12 Na 0 Ca 10 K_DRi 0 K_AHPi 0.1 K_Ci 40 K_Ai 0 ap10_7 ap9_6 0 50 0 1.88 Ca_conc -25.0e12 Na 0 Ca 10 K_DRi 0 K_AHPi 0.1 K_Ci 40 K_Ai 0 ap11_1 ap10_1 -50 0 0 1.20 Ca_conc -25.0e12 Na 0 Ca 10 K_DRi 0 K_AHPi 0.1 K_Ci 40 K_Ai 0 ap11_2 ap10_2 0 50 0 1.20 Ca_conc -25.0e12 Na 0 Ca 10 K_DRi 0 K_AHPi 0.1 K_Ci 40 K_Ai 0 ap11_3 ap10_3 0 49.5 7.05 1.88 Ca_conc -25.0e12 Na 0 Ca 10 K_DRi 0 K_AHPi 0.1 K_Ci 40 K_Ai 0 ap11_4 ap10_4 -50 0 0 0.76 Ca_conc -25.0e12 Na 0 Ca 10 K_DRi 0 K_AHPi 0.1 K_Ci 40 K_Ai 0 ap11_5 ap10_5 0 48 14 0.76 Ca_conc -25.0e12 Na 0 Ca 10 K_DRi 0 K_AHPi 0.1 K_Ci 40 K_Ai 0 ap11_6 ap10_6 -48 0 14 1.20 Ca_conc -25.0e12 Na 0 Ca 10 K_DRi 0 K_AHPi 0.1 K_Ci 40 K_Ai 0 ap11_7 ap10_7 0 50 0 1.88 Ca_conc -25.0e12 Na 0 Ca 10 K_DRi 0 K_AHPi 0.1 K_Ci 40 K_Ai 0 bas3 soma 0 0 -50 3.00 Ca_conc -123.0e12 Na 50 Ca 10 K_DRi 150 K_AHPi 0.1 K_Ci 80 K_Ai 5 bas2_1 bas3 45.83 0 -20 1.88 Ca_conc -164.0e12 Na 0 Ca 10 K_DRi 0 K_AHPi 0.1 K_Ci 40 K_Ai 5 AMPA -4.0e-9 bas2_2 bas3 0 -45.83 -20 1.88 Ca_conc -164.0e12 Na 0 Ca 10 K_DRi 0 K_AHPi 0.1 K_Ci 40 K_Ai 5 AMPA -4.0e-9 bas1_1 bas2_1 0 -45.83 -20 1.20 Ca_conc -148.0e12 Na 0 Ca 10 K_DRi 0 K_AHPi 0.1 K_Ci 40 K_Ai 0 AMPA -4.0e-9 bas1_2 bas2_1 0 45.83 -20 1.20 Ca_conc -148.0e12 Na 0 Ca 10 K_DRi 0 K_AHPi 0.1 K_Ci 40 K_Ai 0 AMPA -4.0e-9 // for the axonal compartments, RM and RA have different values *set_compt_param RM 0.1 //ohm*m^-2 *set_compt_param RA 1.0 //ohm*m^-1 axonIS soma -75 0 0 2.00 NaA 5000 K_DRAi 2500 ax axonIS 0 -75 0 1.00 NaA 5000 K_DRAi 2500 spikegen 0 // in the case of the spike-generator spikegen "0"V is the threshold