Small networks of fast-spiking striatal interneurons were modeled in order
to study the effects of gap junction coupling on synchronization of
spiking. The interneuron model provided with the simulation was developed
by Kotaleski et al. (2006) and has 127 compartments with a soma connected
to three primary dendritic branches, which divide into secondary and
tertiary branches. Fast sodium channels and three types of potassium
channels reproduce action potential shape and firing patterns measured
experimentally.
The downloadable zip archive file for the simulation FSGJ_Hjorth2009.zip
contains a README.txt file with a description of the simulation and
instructions for running it. Note that both MATLAB and GENESIS are used,
with MATLAB creating the cell parameter file for GENESIS, and then
starting GENESIS.
References:
Hjorth J, Blackwell KT, Kotaleski JH (2009) Gap junctions between striatal
fast spiking interneurons regulate spiking activity and synchronisation as
a function of cortical activity. J Neurosci 29:5276-5286
Kotaleski, J. H., Plenz, D. and Blackwell, K. T. (2006) Using potassium
currents to solve signal-to-noise problems in inhibitory feedforward
networks of the striatum. J. Neurophysiol. 95:331-341.