The activity of mid brain dopamine (DA) neurons
resembles the reward prediction error signal of the Temporal
Difference (TD) model. Dopamine acting at D1 receptor activates
adenylate cyclase through the coupling of D1 receptors
with Gs/olf . The complex of adenylate cyclase activates and
increases the intracellular levels of cAMP and thereby stimulating
cAMP dependent protein kinase and increasing the state
of phosphorylation of DARPP-32 (dopamine and cyclic AMPregulated
phosphoprotein, M, = 32,000). DARPP-32 plays an
important role in autophosphorylation of calcium calmodulin
dependent protein kinaseII (CaMKII) which is crucial for
prolongation of long term potentiation (LTP). Here we verified
the effect of pre–synaptic re–uptake of dopamine by dopamine
transporter on the phosphorylation of DARPP-32 and found
that the phosphorylation of DARPP-32 is unaffected by pre–
synaptic re–uptake. Further we have seen that the DARPP-32
phosphorylation does not change with the change in the DA or
D1R concentrations
A Computational Study of Pre-Synaptic Re-uptake of Dopamine on Phosphorylation of DARPP-32
Publication Year:
(2009)
Journal or Book Reference:
Proceedings of International Joint Conference on Neural Networks, Atlanta, Georgia, USA, June 14-19, 2009