GENESIS: Publication

Related Documentation:
Parameter Estimation, Channel Kinetics, Channel Densities

De Schutter: Purkinje Cell Model

Abstract Item 2

The ionic channels were distributed differentially over three zones of the model, with Na+ channels in the soma, fast K+ channels in the soma and main dendrite, and Ca2+ channels and Ca2+- activated K+ channels in the entire dendrite. Channel densities in the model were varied until it could reproduce Purkinje cell responses to current injections in the soma or dendrite, as observed in slice recordings.