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Related Documentation:

De Schutter: Purkinje Cell Model

Abstract Item 7

Finally, the model was used to study the probable accuracy of experimental voltage-clamp data. Whole-cell patch-clamp conditions were simulated by blocking most of the K+ currents in the model. The increased electrotonic length due to the active dendritic membrane caused space clamp to fail, resulting in membrane potentials in proximal and distal dendrites that differed critically from the holding potential in the soma.